Disruption of Thyroid Hormone Receptor–Mediated Transcription and Thyroid Hormone–Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenyl Ethers
نویسندگان
چکیده
منابع مشابه
Disruption of Thyroid Hormone Receptor–Mediated Transcription and Thyroid Hormone–Induced Purkinje Cell Dendrite Arborization by Polybrominated Diphenyl Ethers
BACKGROUND Polybrominated diphenyl ethers (PBDEs) have been used as flame retardants and are becoming a ubiquitous environmental contaminant. Adverse effects in the developing brain are of great health concern. OBJECTIVE We investigated the effect of PBDEs/hydroxylated PBDEs (OH-PBDEs) on thyroid hormone (TH) receptor (TR)-mediated transcription and on TH-induced dendrite arborization of cere...
متن کاملThe feline thyroid gland: a model for endocrine disruption by polybrominated diphenyl ethers (PBDEs)?
The role of polybrominated diphenyl ethers (PBDE) was investigated in the occurrence of feline hyperthyroidism (FH) by evaluating 15 PBDE congeners in serum from 62 client-owned (21 euthyroid, 41 hyperthyroid) and 10 feral cats. Total serum PBDE concentrations in euthyroid cats were not significantly different from those of hyperthyroid cats. Total serum PBDE in feral cats were significantly lo...
متن کاملEffects of polybrominated diphenyl ethers on thyroid hormone, neurodevelopment and fertility in rodents and humans.
Polybrominated diphenyl ethers (PBDEs) are used as flame retardants. Due to their widespread use in many consumer products, PBDEs can be found in food as well as in the environment. Their presence has also been found in the human serum, human adipose tissue and human breast milk. Results of experimental studies suggest that the presence of PBDE in the environment is not neutral to our health. I...
متن کاملAssociation of Polybrominated Diphenyl Ethers (PBDEs) and Polychlorinated Biphenyls (PCBs) with Hyperthyroidism in Domestic Felines, Sentinels for Thyroid Hormone Disruption
BACKGROUND Hyperthyroidism is the most common endocrine disorder observed in domestic felines; however, its etiology is largely unknown. Two classes of persistent organic pollutants, polybrominated diphenyl ethers (PBDEs) and polychlorinated biphenyls (PCBs) are known to interfere with thyroid hormone (TH) signaling and regulation; thus, it is postulated that they contribute to the etiopathogen...
متن کاملDevelopmental exposure to brominated diphenyl ethers results in thyroid hormone disruption.
The objective of the current study was to characterize the effects of DE-71 (a commercial polybrominated diphenyl ether mixture containing mostly tetra- and penta-bromodiphenyl ethers) on thyroid hormones and hepatic enzyme activity in offspring, following perinatal maternal exposure. Primiparous Long-Evans rats were orally administered DE-71 (0, 1, 10, and 30 mg/kg/day) in corn oil from gestat...
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ژورنال
عنوان ژورنال: Environmental Health Perspectives
سال: 2011
ISSN: 0091-6765,1552-9924
DOI: 10.1289/ehp.1002065